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UTI Treatment: Beyond the Guidelines

Clinical Thought

Diagnosis and treatment of complicated urinary tract infection (cUTI) pose a significant challenge, especially when misdiagnosis and inappropriate treatment can lead to persistent colonization with extensively drug-resistant uropathogens. Read my answers to learner questions about the nuances of cUTI care.

Released: February 18, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This educational activity is supported by an independent medical education grant from GSK.

GSK

Target Audience

This activity is intended for healthcare professionals, including physicians, nurse practitioners, physician associates, and pharmacists, who provide care for patients with complicated UTIs, including healthcare professionals practicing in infectious diseases, internal medicine, hospital medicine, urology, or emergency medicine.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Assess the burden of complicated UTIs on patients and the healthcare system

  • Develop evidence-based strategies for selecting empiric antibiotics for patients with complicated UTI

  • Tailor definitive antibiotic therapy for complicated UTIs, incorporating oral agents when appropriate

Disclosure

Primary Author

Nicolás Cortés-Penfield, MD, FACP, FIDSA, has no relevant financial relationships to disclose.