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PURPOSE 2 Longer-Term Analysis: Phase III Trial of HIV PreP With Twice-Yearly LEN vs Daily FTC/TDF in Cisgender Men and Gender Diverse People

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In a longer-term analysis of the phase III PURPOSE 2 trial, twice-yearly lenacapavir continued to be highly effective and safe in preventing HIV infection vs daily FTC/TDF in cisgender men, transgender women, and gender diverse people who have sex with men.

Released: February 27, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by independent educational grants from Gilead Sciences, Inc., Merck & Co., Inc., Rahway, NJ, USA, and ViiV Healthcare.

Gilead Sciences, Inc.

Merck & Co., Inc., Rahway, NJ, USA

ViiV Healthcare

Target Audience

This activity is intended for physicians, pharmacists, registered nurses, and other healthcare professionals who care for people living with or at risk of HIV infection.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Appropriately apply and counsel patients regarding the clinical role(s) of new and investigational ART regimens and strategies

  • Devise HIV management strategies based on the results of recent clinical studies of established antiretroviral agents

  • Integrate the latest scientific findings to develop and optimize effective HIV prevention interventions