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Optimizing Oral and Outpatient Therapy in ABSSSI—Balancing Efficacy, Safety, and Stewardship

Clinical Thought

Modern management of ABSSSI increasingly emphasizes outpatient care. Read on to learn how to assess risk and select appropriate agents to minimize unnecessary hospitalizations while ensuring effective, patient-centered therapy and reducing antibiotic overuse.

Released: December 26, 2025

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Paratek Pharmaceuticals, Inc.

Paratek Pharmaceuticals, Inc.

Target Audience

This activity is intended for healthcare professionals who care for patients with acute bacterial skin and skin structure infections, including physicians, nurse practitioners, and physician associates working in primary care, urgent care, and emergency medicine settings.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Design antibiotic regimens for acute bacterial skin and skin structure infections in patients at risk for drug-resistant pathogens

  • Optimize antibiotics for adults with acute bacterial skin and skin structure infections and high risk for Clostridioides difficile superinfections

  • Select outpatient antibiotic therapy for complicated acute bacterial skin and skin structure infections to maximize safety and efficacy

Disclosure

Primary Author

Thomas P. Lodise, PharmD, PhD: consultant/advisor/speaker: Astellas, GSK, Melinta, Merck, Paratek, Shionogi.