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Same-Day PrEP Guidance

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Same-day PrEP can help reduce missed opportunities early in the PrEP care cascade by supporting timely initiation of HIV prevention for eligible patients. Download this clinician resource to review key data and recommendations for the implementation of same-day PrEP. This handy guide includes quick reference tables and guidance on starting same-day PrEP and a practical checklist for building or refining a same-day PrEP protocol in your clinical practice.

Released: July 20, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Gilead Sciences, Inc.

Gilead Sciences, Inc.

Target Audience

This activity is intended for physicians, pharmacists, registered nurses, and other healthcare professionals (both specialists and generalists) who provide PrEP.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Apply current IAS-USA and CDC guideline recommendations to determine when rapid or same-day PrEP is appropriate

  • Implement efficient, safe, and sustainable clinical workflows that support same day PrEP initiation across varied practice settings

Financial Disclosures

Primary Author

Kenneth H. Mayer, MD: researcher: Gilead, Merck, ViiV; consultant/advisor/speaker: Gilead, Merck, ViiV.

Sarah E. Rowan, MD, has no relevant financial relationships to disclose.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for drafting educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.