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ART Switch: When and Why

Clinical Thought

Advances in modern antiretroviral therapy (ART) for HIV have shifted the treatment paradigm away from solely prioritizing virologic suppression towards individualized care. Sometimes, this means considering an ART switch for people who are already on suppressive regimens, even those who report satisfaction with their current regimen. Here, I discuss the when and why of switching ART for people with HIV on virologically suppressive regimens. 

Released: August 04, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported through an independent educational grant from Merck & Co., Inc., Rahway, NJ, USA.

Merck & Co., Inc., Rahway, NJ, USA

Partners

Goldschmidt Collective

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Target Audience

This activity is intended for physicians, pharmacists, registered nurses, and other healthcare professionals who provide care for people living with HIV.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Guide clinical conversations to ascertain instances when patients may wish to switch a suppressive regimen 

  • Implement ART regimen switches in virologically suppressed individuals to support optimal long-term clinical outcomes

  • Apply emerging ART agents to expand the range of options for tailoring an optimal, individualized regimen for each person living with HIV

Financial Disclosures

Primary Author

Cristina Gruta, PharmD, AAHIVP, has no relevant financial relationships to disclose.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.