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Precision Diagnosis and Disease Biology of TGCT—Establishing the Rationale for CSF1R Targeting

Slideset

This downloadable slide deck reviews the clinical presentation, diagnosis, disease biology, and multidisciplinary management of tenosynovial giant cell tumor (TGCT), a rare, benign but locally aggressive synovial neoplasm that can cause substantial pain, swelling, stiffness, recurrent effusions, and functional impairment. The activity distinguishes localized from diffuse-type TGCT, including differences in growth patterns, recurrence risk, and the limitations of surgery in infiltrative disease. It also examines the roles of MRI, CT, and pathology in confirming the diagnosis, defining disease extent, identifying bone involvement, and excluding malignant mimics. In addition, the slides show how CSF1 overexpression and recruitment of CSF1R-expressing inflammatory cells contribute to tumor growth and symptom burden, providing the biologic rationale for CSF1R-directed therapy. These concepts are important for improving early recognition, referral to experienced multidisciplinary teams, and individualized treatment decisions that balance disease control, procedural morbidity, symptom relief, and preservation of joint function.

Released: September 01, 2026

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Faculty

Emanuela Palmerini

Emanuela Palmerini, MD, PhD

Professor of Medicine
Department of Oncology
Leonard M. Miller School of Medicine
University of Miami
Sylvester Comprehensive Cancer Center
Miami, Florida

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

Daiichi Sankyo, Inc.

Target Audience

This program is intended for oncologists, physician associates, nurses, nurse practitioners, clinical nurse specialists, pharmacists, and other healthcare professionals who care for patients with tenosynovial giant cell tumors.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize the distinguishing clinical, radiologic, and pathologic features of localized and diffuse TGCT to support timely and accurate diagnosis

  • Apply shared decision-making techniques to align treatment plans with individual patient values, preferences, and quality-of-life considerations in TGCT management

Financial Disclosures

Primary Author

Emanuela Palmerini, MD, PhD: consultant/advisor/speaker: Daiichi Sankyo, Deciphera, EMD Serono, Servier, SpringWorks.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for data analysis or summarization influencing content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.