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How I Am Incorporating GPRC5D-Directed Bispecific Antibody Therapy Into Multiple Myeloma Care in My Practice

Clinical Thought

This expert commentary examines the evolving role of GPRC5D-directed therapy in multiple myeloma, including the biologic rationale for targeting GPRC5D and clinical evidence supporting talquetamab across treatment settings. It also explores emerging approaches to sequencing and combining GPRC5D- and BCMA-directed therapies, ongoing studies evaluating earlier-line use such as the phase III MonumenTAL-3 trial, and practical strategies for recognizing and managing unique toxicities associated with GPRC5D-targeted treatment like skin, nail, and taste changes.

Released: October 02, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from Johnson & Johnson.

Johnson & Johnson

Target Audience

This activity is designed for hematologists, oncologists, and other healthcare professionals who care for patients with multiple myeloma.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the biologic rationale for targeting GPRC5D in multiple myeloma and its role within the evolving immunotherapy landscape

  • Apply evidence-based strategies for sequencing GPRC5D bispecific antibodies within current treatment paradigms

  • Identify and manage key safety and tolerability considerations unique to GPRC5D-directed bispecific antibody therapy

Financial Disclosures

Primary Author

Amrita Krishnan, MD, FACP: consultant/advisor/speaker: AbbVie, AstraZeneca, Bristol Myers Squibb, Johnson & Johnson, Pfizer, Roche, Sanofi; publicly traded stocks/stock options: Arcellx, Bristol Myers Squibb.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content and generating transcript(s) from audio/video files. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.