Faculty

Jesus Berdeja, MD

Director of Multiple Myeloma Research
Greco-Hainsworth Centers for Research
Tennessee Oncology
Nashville, Tennessee

Amrita Krishnan, MD, FACP

Director, Judy and Bernard Center for Myeloma, City of Hope
Nason Hollingsworth Family Chair Myeloma
Executive Director, Hematology, City of Hope Orange County
Professor Hematology/HCT
Irvine, California

Niels van de Donk, MD, PhD

Professor of Hematology
Department of Hematology
Amsterdam UMC, Location VUmc
Amsterdam, Netherlands

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

Supporters

Supported by an educational grant from Bristol Myers Squibb.

Bristol Myers Squibb

Target Audience

This activity is intended for hematologists, oncologists, and other healthcare professionals who care for patients with multiple myeloma.

Program Learning Goal

The goal of this activity is to improve the knowledge, confidence, and competence of learners in management of patients with multiple myeloma.

Learning Objectives

Upon completion of this activity, participants should be able to:

Evaluate how differences in cereblon affinity and binding potency influence the antimyeloma activity of individual CELMoD agents and IMiDs
Appraise emerging data for CELMoD agents and their potential therapeutic roles across the disease continuum of multiple myeloma
Assess the clinical implication and association of achieving MRD negativity on treatment as a surrogate marker of long-term outcomes
Identify patients with multiple myeloma who may be eligible for ongoing clinical trials of CELMoD agent-based therapies

Disclosure

Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Jesus Berdeja, MD: researcher (paid to institution): AstraZeneca, Bristol Myers Squibb, C4 Therapeutics, Caribou Biosciences, CARsgen, Cartesian, Genentech, GlaxoSmithKline, Gracell, Ichnos Sciences, Johnson & Johnson, Juno, K36 Therapeutics, Karyopharm, Kite, Moderna, Pfizer, Regeneron, Roche, Sanofi; consultant: AstraZeneca, Bristol Myers Squibb, Galapagos, Johnson & Johnson, Kite, Kyowa Kirin, Pfizer, Regeneron, Roche, Sebia; speaker: Janssen.

Amrita Krishnan, MD, FACP: consultant/advisor/speaker: AstraZeneca, Bristol Myers Squibb, GSK, Johnson & Johnson, Pfizer, Roche, Sanofi; individual publicly traded stock/stock options: Arcellx, Bristol Myers Squibb.

Niels van de Donk, MD, PhD: researcher: Amgen, Bristol Myers Squibb, Celgene, Cellectis, Janssen, Novartis; advisor (paid to institution): AbbVie, Adaptive, Amgen, Bayer, Bristol Myers Squibb, Celgene, Galapagos, Janssen, Kite, Merck, Novartis, Pfizer, Roche, Sanofi, Servier, Takeda.

The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 2 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from December 29, 2025, through June 28, 2026:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through Clinical Care Options, LLC dba Decera Clinical Education Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC dba Decera Clinical Education permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

CME Passport

The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit cmepassport.org to create your account.

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Myeloma Myth Busters: Investigating the Now, Soon, and Future Clinical Implications of CELMoDs

Video