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GPRC5D-Directed Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma: Clinical Evidence and Practice Implications

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These slides cover the evolving role of GPRC5D-directed bispecific antibodies in relapsed/refractory multiple myeloma. Take a look at evidence supporting CAR T-cell therapies and bispecific antibodies across the treatment continuum and explore considerations for treatment selection and sequencing of GPRC5D-directed therapy in the current treatment landscape, emerging data for talquetamab-based strategies, and factors that may influence outcomes following prior targeted therapy. The activity also addresses practical approaches to GPRC5D-directed bispecific antibody dosing, toxicity prevention, management, and patient counseling to support safe and effective integration of talquetamab into clinical practice.

Released: September 03, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from Johnson & Johnson.

Johnson & Johnson

Target Audience

This activity is designed for hematologists, oncologists, nurses, physician associates, pharmacists, and other healthcare professionals who care for patients with multiple myeloma.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the biologic rationale for targeting GPRC5D in multiple myeloma and its role within the evolving immunotherapy landscape

  • Apply evidence-based strategies for sequencing GPRC5D bispecific antibodies within current treatment paradigms

  • Identify and manage key safety and tolerability considerations unique to GPRC5D-directed bispecific antibody therapy

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.