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Interactive Case Challenge: Diagnosing and Managing a Patient With Essential Thrombocythemia

Case Challenge

In this interactive case challenge, make clinical decisions to optimize the diagnosis and treatment of a patient with essential thrombocythemia.

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: April 06, 2026

Expiration: October 05, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Merck Sharp & Dohme LLC.

Merck Sharp & Dohme, LLC

Target Audience

This activity is intended for hematologists and other healthcare professionals caring for patients with essential thrombocythemia and polycythemia vera.

Program Learning Goal

This activity will equip learners’ to recognize, diagnose, and stratify risk in patients with ET and PV, while preparing clinical practices to integrate emerging second-line therapies. By strengthening early identification of MPN-related thrombotic events, applying dynamic prognostic models, and improving shared decision-making, the program supports timely, patient-aligned care to reduce complications and improve outcomes.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify underlying MPNs such as ET and PV in patients presenting with thrombotic events that are otherwise unexplained

  • Diagnose patients with ET and PV, including bone marrow biopsies and assessment of risk of thrombotic events

  • Engage patients with ET and PV in shared decision-making to better align treatment with both best practices and patient preferences on risks and benefits

  • Prepare clinical practice to incorporate new second-line agents for ET and PV upon approval

Disclosure

Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Claire Harrison, MD, FRCP, FRCPath: consultant/advisor/speaker: AOP, Galecto, GSK, Inctye, Johnson & Johnson, Novartis, Syntara.

Jean-Jacques Kiladjian, MD, PhD: consultant/advisor/speaker: AbbVie, AOP, Bristol Myers Squibb, GSK, Novartis.

The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from April 06, 2026, through October 05, 2026:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

Upon completion of this activity, participants should be able to:

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit cmepassport.org to create your account.