Content - ASH25 Multiple Myeloma | Decera Clinical Education

Introduction

In this text-based module, Shaji Kumar, MD, and Sagar Lonial, MD, FACP, FASCO, discuss key findings in multiple myeloma (MM) presented at the 2025 American Society of Hematology (ASH) Annual Meeting.

The key points discussed in this module are illustrated with thumbnails from the accompanying downloadable PowerPoint slidesets, which can be found here or downloaded by clicking any of the slide thumbnails in the module alongside the expert commentary.

Please note that Decera Clinical Education plans to measure the educational impact of this activity. Some questions will be asked twice: once at the beginning of the activity, and once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your individual responses will not be shared. Thank you in advance for helping us assess the impact of this education. 

Before continuing with this educational activity, please take a moment to answer the following questions.

 How many people with MM do you provide care for in a typical month?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
>20
F.
Not applicable

For those who practice in academic or community settings, please indicate your practice setting:

A.
Academic
B.
Community
C.
Not applicable

Which of the following bispecific antibody therapies, when used as consolidation therapy after standard CAR T-cell therapy in patients with relapsed/refractory (R/R) MM, was associated with high rates of measurable residual disease (MRD)–negative complete response (CR) at 1 year post CAR T-cell therapy infusion?

A.
Cevostamab
B.
Elranatamab
C.
Linvoseltamab
D.
Talquetamab

In the MajesTEC-3 phase III trial that enrolled patients with previously treated MM, which of the following findings was reported with the combination of daratumumab plus teclistamab compared with a standard daratumumab-based regimen (DPd or DVd)?

A.
Significantly improved progression-free survival (PFS) only
B.
Significantly improved PFS and overall survival (OS)
C.
A substantially higher incidence of grade 3/4 infections
D.
A moderately higher rate of discontinuation due to treatment-emergent adverse events (AEs)

You are counseling a patient with R/R MM who has newly documented extramedullary disease (EMD). Based on recently reported results from the RedirecTT-1 trial that evaluated talquetamab plus teclistamab, which of the following would be accurate information to share with them?

A.
Response rates were higher in patients with organ-based EMD vs nonorgan EMD
B.
Response rates were similar regardless of disease burden
C.
The majority of patients with a response achieved a CR or better
D.
The median duration of response (DoR) was a little less than 1 year

You are discussing treatment options with a patient who has standard‑risk relapsed MM who is considering CAR‑T therapy. Based on an analysis of extended outcomes with ciltacabtagene autoleucel (cilta‑cel) in patients with standard‑risk relapsed MM reported by Costa and colleagues at ASH 2025, which of the following would you tell the patient is expected regarding PFS 30 months after CAR T-cell infusion?

A.
Most patients experience disease progression by that time
B.
Approximately half of patients experience disease progression by that time
C.
Most patients do not experience disease progression by that time
D.
All patients remained without disease progression by that time

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Emerging Data and Clinical Implications in Multiple Myeloma: ASH 2025 Highlights

Shaji K. Kumar, MD

Sagar Lonial, MD, FACP. FASCO

Activity

Introduction

How many people with MM do you provide care for in a typical month?

For those who practice in academic or community settings, please indicate your practice setting:

In the MajesTEC-3 phase III trial that enrolled patients with previously treated MM, which of the following findings was reported with the combination of daratumumab plus teclistamab compared with a standard daratumumab-based regimen (DPd or DVd)?

You are counseling a patient with R/R MM who has newly documented extramedullary disease (EMD). Based on recently reported results from the RedirecTT-1 trial that evaluated talquetamab plus teclistamab, which of the following would be accurate information to share with them?

Emerging Data and Clinical Implications in Multiple Myeloma: ASH 2025 Highlights

Shaji K. Kumar, MD

Sagar Lonial, MD, FACP. FASCO

Activity

Introduction

How many people with MM do you provide care for in a typical month?​

For those who practice in academic or community settings, please indicate your practice setting:

In the MajesTEC-3 phase III trial that enrolled patients with previously treated MM, which of the following findings was reported with the combination of daratumumab plus teclistamab compared with a standard daratumumab-based regimen (DPd or DVd)?

You are counseling a patient with R/R MM who has newly documented extramedullary disease (EMD). Based on recently reported results from the RedirecTT-1 trial that evaluated talquetamab plus teclistamab, which of the following would be accurate information to share with them?

 How many people with MM do you provide care for in a typical month?