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Second line PBC Therapy

CE / CME

Choosing Optimal Second-line Therapy for PBC  

Pharmacists: 0.75 contact hour (0.075 CEUs)

Physicians: maximum of 0.75 AMA PRA Category 1 Credit

Nurse Practitioners/Nurses: 0.75 Nursing contact hour

Released: March 31, 2026

Expiration: March 30, 2027

Activity

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Introduction

In this module, Gideon Hirschfield, MA, MB BChir, FRCP, PhD, discusses second-line treatment for primary biliary cholangitis (PBC), including how to identify nonresponders to first-line treatment and how to define goals of second-line therapy.

The key points discussed in this module are illustrated with thumbnails from the accompanying downloadable PowerPoint slideset, which can be found here or downloaded by clicking on any of the slide thumbnails in the module alongside the expert commentary.

How many people with PBC do you provide care for in a typical month?

For those who practice in academic or community settings, please indicate your practice setting:

If you practice in gastroenterology, is hepatology your specialty?

A 35-year-old woman with PBC has an alkaline phosphatase (ALP) of 2.3 times the upper limit of normal after 6 months on weight-based ursodeoxycholic acid (UDCA) and does not want to use birth control. What would you recommend next?

A person with PBC was started on weight-based UDCA. At the 6-month evaluation, their severe pruritus is not responding to cholestyramine, and their ALP has decreased from 2.6 to 2.0 times the upper limit of normal. What would you recommend?