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Avoid These Common Misconceptions and Mistakes About PBC Second-Line PBC Therapy

Clinical Thought

Learn how to avoid common pitfalls in second-line therapy for PBC like delaying escalation or stopping UDCA. Here’s my take on optimal response targets and a simple algorithm to help you treat PBC to ideal goals.

Released: February 17, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Gilead Sciences, Inc.

Gilead Sciences, Inc.

Target Audience

This activity is intended for physicians, including hepatologists and gastroenterologists, nurse practitioners, physician associates, nurses, pharmacists, and other healthcare professionals involved in the care of patients with PBC.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Develop personalized management plans for patients with PBC based on individual risk, comorbidities, and symptoms

  • Apply best practices to select appropriate second-line PBC therapy in a timely manner

Disclosure

Primary Author

Gideon Hirschfield, MB BChir, FRCP, PhD: consultant/advisor/speaker: Advanz, Gilead, GSK, Kezar, Kowa, Intercept, Ipsen, Mirum, Pliant.