Faculty

Joseph F. Goldberg, MD

Clinical Professor of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Lisa M. Harding, MD

Medical Director
Mood Institute
Assistant Clinical Professor of Psychiatry
Yale School of Medicine
New Haven, Connecticut

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

Supporters

This activity is supported by an educational grant from Intra-Cellular Therapies, Inc.

Intra-Cellular Therapies, Inc.

Target Audience

This activity is intended for healthcare professionals caring for patients with major depressive disorder, including physicians (psychiatrists and family medicine/primary care), nurse practitioners, physician associates, registered nurses, pharmacists, psychologists, and social workers

Program Learning Goal

The goal of this activity is to improve the knowledge, competence, and performance of learners in effort to optimize treatment for patients with Major Depressive Disorder.

Learning Objectives

Upon completion of this activity, participants should be able to:

Assess optimal timing and clinical rationale for switching or augmenting treatment in patients with MDD
Evaluate the pharmacologic profiles, efficacy, and safety of approved adjunctive therapies for adults with MDD that improve residual symptoms, including anhedonia and cognitive impairment
Apply current guideline- and evidence-based strategies to optimize dosing and titration of adjunctive therapies for adults with MDD who exhibit residual symptoms
Implement strategies for optimizing the management of persistent symptoms for complex or special populations with MDD to optimize long-term outcomes and functional recovery

Financial Disclosures

Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Joseph F. Goldberg, MD: consultant/advisor/speaker: AbbVie, Alkermes, Almatica, Alvogen, Axsome, Bristol Myers Squibb, Compass Pathways, Neurelis, Neurocrine, Neuroma, Otsuka, Puretech, Seaport, Vanda.

Lisa M. Harding, MD: consultant/advisor/speaker: AbbVie, DKBMED, GH Research, Janssen, Lilly, Otsuka, Takeda.

The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose, except Jeremy Schreiber, MSN, APRN, PMHNP-BC and Rebecca DePalma, DMSc, PA-C: as noted below:

Jeremy Schreiber, MSN, APRN, PMHNP-BC: consultant/advisor/speaker: Alkermes, Axsome, Biogen, Bristol Myers Squibb, Intra-Cellular, Janssen, Johnson & Johnson, Neurocrine, Sage, Supernus, Teva, Vanda; individual publicly traded stocks/stock options: Biogen, Bristol Myers Squibb, Sage.

Rebecca DePalma, DMSc, PA-C: consultant/advisor/speaker: AbbVie, Bristol Myers Squibb.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from October 27, 2026, through October 26, 2027:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Additional Disclosures

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Generative artificial intelligence (AI) tools were used for generating transcript(s) from audio/video file. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development

The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1 contact hour.

Continuing Pharmacy Education

Clinical Care Options, LLC dba Decera Clinical Education designates this continuing education activity for 1 contact hour (0.10 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number: XXXX

Type of Activity: Application

Upon successfully completing the post-test with a score of 65% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

Physician Associate Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1 AAPA Category 1 CME credit. Approval is valid until October 26, 2027. PAs should only claim credit commensurate with the extent of their participation.

Psychologist Continuing Education

Continuing education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs.

This activity offers 1 continuing education credit for psychologists.

Social Work Continuing Education

As a Jointly Accredited Organization, Clinical Care Options, LLC dba Decera Clinical Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this course receive 1 clinical continuing education credit.

IPCE Credit Designation

A logo for a credit companyAI-generated content may be incorrect.
This activity was planned by and for the healthcare team, and learners will receive 1 Interprofessional Continuing Education (IPCE) credit for learning and change.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported credit. Visit CME cmepassport.org to create your account.

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Advancing Adjunctive Strategies: Optimizing Care for Residual Symptoms in Major Depressive Disorder

Video