Ask AI
ProCE Banner Activity

Shedding Light on the Gray Areas of First-line PBC Therapy: Assessing Treatment Response

Clinical Thought

First-line treatment goals and escalation to second-line therapy can be a little bit of a gray area in primary biliary cholangitis (PBC), sometimes requiring nuance and relying on expert opinion. Read on to learn how I individualize treatment goals and what factors I consider when assessing treatment responses.

Released: March 04, 2026

Review Activity

Share

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

ProCE Banner

Supporters

Supported by an educational grant from Gilead Sciences, Inc.

Gilead Sciences, Inc.

Target Audience

This activity is intended for physicians, including hepatologists and gastroenterologists, nurse practitioners, physician associates, nurses, pharmacists, and other healthcare professionals involved in the care of patients with PBC. 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Evaluate biochemical response to first-line PBC therapy based on optimal timing and criteria

  • Develop personalized management plans for patients with PBC based on individual risk, comorbidities, and symptoms

  • Apply best practices to select appropriate second-line PBC therapy in a timely manner