Ask AI
ProCE Banner Activity

Confounding Cholestasis: Considerations for the Assessment of Late-Onset Disease

Clinical Thought

Late-onset genetic cholestasis, such as progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome (ALGS), is increasingly diagnosed in adolescents and adults with previously unexplained or persistent cholestatic symptoms, like jaundice or pruritus. Read this expert commentary to learn about factors that lead to suspicion of late-onset cholestasis, practical considerations for genetic testing and counseling, and the vital roles of patient networks.

Released: September 29, 2026

Share

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education in partnership with Progressive Familial Intrahepatic Cholestasis (PFIC) Network.

ProCE Banner

Supporters

This activity is supported by Ipsen Biopharmaceuticals, Inc

Ipsen Biopharmaceuticals Inc

Partners

Progressive Familial Intrahepatic Cholestasis (PFIC) Network

ProCE Banner

Target Audience

This activity is intended for hepatologists, gastroenterologists, nurses, nurse practitioners, physician associates, pharmacists, and other healthcare professionals involved in the management of adult patients with or at risk of PFIC and ALGS.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Assess for late-onset and adult-presenting genetic cholestatic disorders in patients with suspected mimics or established diagnoses that warrant reevaluation

Financial Disclosures

Primary Author

Naim Alkhouri, MD, FAASLD, DABON: consultant/advisor/speaker: Gilead, Ipsen.