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On the Horizon: A New Treatment Paradigm for cUTI

Clinical Thought

The landscape of complicated UTI has changed. First, the new IDSA guidelines emphasize assessment of illness severity, evaluation of risk factors for resistant pathogens, consideration of patient-specific variables, and use of local antibiograms to guide empiric treatment. Second, novel antimicrobial agents provide new oral and IV options. Read on to learn how these advances provide greater flexibility to individualize treatment while supporting antimicrobial stewardship goals. 

Released: July 02, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This educational activity is supported by an independent medical education grant from GSK.

GSK

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Target Audience

This activity is intended for healthcare professionals, including physicians, nurse practitioners, physician associates, and pharmacists, who provide care for patients with complicated UTIs, including healthcare professionals practicing in infectious diseases, internal medicine, hospital medicine, urology, or emergency medicine.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Assess the burden of complicated UTIs on patients and the healthcare system

  • Develop evidence-based strategies for selecting empiric antibiotics for patients with complicated UTI

  • Tailor definitive antibiotic therapy for complicated UTIs, incorporating oral agents when appropriate

Financial Disclosures

Primary Author

Richard Colgan, MD, has no relevant financial relationships to disclose.