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MISSION POSSIBLE: Are We Doing Enough to Prevent Acute Pancreatitis in Severe Hypertriglyceridemia?

Clinical Thought

Severe hypertriglyceridemia (sHTG) is a clinically significant yet frequently underrecognized disorder encountered in cardiovascular practice, associated with an increased risk of acute pancreatitis and potentially serious complications. Timely risk recognition, appropriate treatment selection, and effective triglyceride lowering are essential to reducing this risk. This ClinicalThought commentary explores practical strategies for risk assessment, optimizing treatment decisions, and incorporating emerging therapies into clinical practice to improve outcomes for patients with sHTG.

Released: October 30, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

This activity is supported by Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Target Audience

This activity is intended for cardiology physicians, NPs, PAs, and other healthcare professionals involved in the care of patients with sHTG. 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify patients with severe hypertriglyceridemia (sHTG) through appropriate risk assessment, lipid evaluation, and recognition of key clinical indicators

  • Assess current and emerging treatment approaches for severe hypertriglyceridemia, incorporating patient-specific cardiovascular risk factors and comorbidities

  • Apply guideline-based management strategies to optimize triglyceride lowering, improve cardiometabolic health, and reduce the likelihood of acute pancreatitis in patients with sHTG

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.